Fascinating Image No.3

Prepared by A Kim

Difference in size of alpha-synuclein inclusions in distinct individuals with Multiple System Atrophy
Multiple system atrophy (MSA) is characterized by glial cytoplasmic inclusions (GCI) that are composed of pathological aggregates of alpha-synuclein protein in oligodendrocytes in the brain. Interestingly, the size of inclusions vary between individuals with MSA in the same brain regions. Here, we show the putamen of two individuals with MSA, at the same magnification, immunostained for the antibody 5G4, detecting the pathological form of alpha-synuclein. The size of alpha-synuclein inclusions with visible nucleus are significantly different between these two individuals.