Fascinating Image No.4

Prepared by Dr. Shojiro Ichimata

Representative microphotographs of the ‘bird-nest plaques’ in Down syndrome.

Luxol fast blue and hematoxylin and eosin staining (left panel). Immunohistochemistry for amyloid-beta (6F/3D; middle panel) and glial fibrillary acid protein (right panel). Note the ‘bird-nest’-like morphology.

Scale bar = 25 μm